Revealing Cellular Secrets by Cryo-electron Tomography

The Dai Lab is located on the second floor of the Institute for Quantitative Biomedicine on Busch Campus at Rutgers University - New Brunswick. The lab is composed of undergraduate and graduate students, and post-doctoral researchers. Our goal is to integrate biochemistry, molecular genetics and multiscale biomaging technologies to reveal structural information of disease-relevant protein complexes and illuminate dynamic cellular processes. Our research interests include dissecting the aggregation and transmission dynamics of misfolded proteins, building the molecular circuitry of the photosynthetic machinery and characterizing the 3D structure of a fungal-specific membrane protein complex. These structural insights will hopefully guide development of novel therapeutic strategies to treat life-threatening diseases.